Negative Selection of T Cells byHelicobacter pylorias a Model for Bacterial Strain Selection by Immune Evasion

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Negative selection of T cells occurs throughout thymic development.

Thymic positive and negative selections govern the development of a self-MHC-reactive, yet self-tolerant, T cell repertoire. Whether these processes occur independently or sequentially remains controversial. To investigate these issues, we have employed tetrameric peptide-MHC complexes to fluorescently label and monitor polyclonal populations of thymocytes that are specific for moth cytochrome ...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2001

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.167.2.926